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Hisamitsu Ishihara Selected Research

Insulinoma

7/2010The JNK pathway modulates expression and phosphorylation of 4E-BP1 in MIN6 pancreatic beta-cells under oxidative stress conditions.
2/2006Cell type-specific activation of metabolism reveals that beta-cell secretion suppresses glucagon release from alpha-cells in rat pancreatic islets.
5/2002Association of upregulated activity of K(ATP) channels with impaired insulin secretion in UCP1-expressing insulinoma cells.

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Hisamitsu Ishihara Research Topics

Disease

15Type 2 Diabetes Mellitus (MODY)
04/2024 - 07/2004
8Diabetes Mellitus
01/2021 - 02/2006
6Body Weight (Weight, Body)
12/2019 - 02/2005
5Insulin Resistance
12/2023 - 02/2005
4Hypoglycemia (Reactive Hypoglycemia)
01/2020 - 08/2015
3Atherosclerosis
04/2024 - 07/2006
3Insulinoma
07/2010 - 05/2002
2Obesity
12/2023 - 12/2012
2Pancreatitis
08/2020 - 10/2017
2Arteriosclerosis
10/2018 - 08/2011
2Hypertriglyceridemia
10/2017 - 07/2008
2Infections
12/2016 - 02/2007
2Inflammation (Inflammations)
08/2015 - 08/2011
2Hypercholesterolemia
08/2011 - 07/2008
2Hyperglycemia
05/2007 - 01/2005
2Wolfram Syndrome (Syndrome, Wolfram)
10/2006 - 05/2006
2Optic Atrophy
10/2006 - 05/2006
2Metabolic Syndrome (Dysmetabolic Syndrome X)
07/2006 - 03/2006
1Cardiovascular Diseases (Cardiovascular Disease)
04/2024
1Hyperglycemic Hyperosmolar Nonketotic Coma (Nonketotic Hyperglycemic Coma)
12/2023
1Hypernatremia
01/2022
1Fibrosis (Cirrhosis)
01/2022
1Fatty Liver
10/2021
1Polyneuropathies (Polyneuropathy)
08/2021
1Liver Diseases (Liver Disease)
08/2021
1Diabetic Angiopathies (Diabetic Angiopathy)
08/2021
1Tuberculosis (Tuberculoses)
01/2021
1Suppuration
01/2021
1Granuloma
01/2021
1Myocarditis (Carditis)
08/2020
1Peripheral Nervous System Diseases (PNS Diseases)
05/2020
1Cognitive Dysfunction
05/2020
1Optic Neuritis (Retrobulbar Neuritis)
04/2020
1Acid-Base Imbalance
04/2020
1Acidosis
04/2020
1Renal Tubular Acidosis (Distal Renal Tubular Acidosis)
04/2020
1Hyperkalemia
04/2020
1Hypertension (High Blood Pressure)
04/2020
1Hyponatremia
04/2020
1Vision Disorders (Hemeralopia)
04/2020
1Postoperative Nausea and Vomiting (PONV)
01/2020
1Empty Sella Syndrome
01/2020
1Heartburn (Pyrosis)
01/2020
1Adrenal Insufficiency (Adrenal Gland Hypofunction)
01/2020
1Osteoarthritis
01/2020
1Cellulitis
01/2020
1Hemorrhage
01/2020
1Nausea
01/2020

Drug/Important Bio-Agent (IBA)

11Glucose (Dextrose)FDA LinkGeneric
04/2024 - 07/2006
7Insulin (Novolin)FDA Link
01/2020 - 01/2005
6ipragliflozinIBA
04/2024 - 12/2016
4Metformin (Glucophage)FDA LinkGeneric
12/2023 - 01/2015
4LeptinIBA
12/2019 - 02/2005
3SodiumIBA
12/2023 - 10/2018
3AdiponectinIBA
12/2019 - 07/2006
3Glucagon (Glukagon)FDA Link
12/2019 - 02/2006
3Blood Glucose (Blood Sugar)IBA
08/2018 - 01/2005
2LiraglutideFDA Link
04/2024 - 10/2021
2Glucagon-Like Peptide-1 Receptor AgonistsIBA
04/2024 - 08/2018
2Glucagon-Like Peptide-1 ReceptorIBA
04/2024 - 08/2018
2Sodium-Glucose Transport ProteinsIBA
04/2024 - 01/2019
2Sitagliptin Phosphate (Januvia)FDA Link
12/2023 - 01/2015
2Glycated Hemoglobin (Glycosylated Hemoglobin)IBA
12/2023 - 12/2019
2Biomarkers (Surrogate Marker)IBA
01/2023 - 08/2020
2AmylasesFDA Link
08/2020 - 10/2017
2Adrenal Cortex Hormones (Corticosteroids)IBA
04/2020 - 01/2020
26- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA
01/2020 - 10/2018
2glimepiride (Amarel)FDA LinkGeneric
01/2020 - 10/2018
2Hypoglycemic Agents (Hypoglycemics)IBA
01/2020 - 06/2019
2Dipeptidyl-Peptidase IV InhibitorsIBA
10/2018 - 08/2015
2Triglycerides (Triacylglycerol)IBA
10/2017 - 08/2012
2IncretinsIBA
08/2015 - 01/2015
1Streptozocin (Streptozotocin)FDA Link
04/2024
1Apolipoproteins E (ApoE)IBA
04/2024
1Niacinamide (Nicotinamide)FDA LinkGeneric
04/2024
1SymportersIBA
12/2023
1Fatty Acids (Saturated Fatty Acids)IBA
01/2023
1Retinaldehyde (Retinal)IBA
01/2023
1Alanine Transaminase (SGPT)IBA
01/2022
1Aspartate Aminotransferases (Aspartate Transaminase)IBA
01/2022
1Antihypertensive Agents (Antihypertensives)IBA
01/2022
1XanthineIBA
08/2021
1Xanthine DehydrogenaseIBA
08/2021
1HDL CholesterolIBA
08/2021
1HypoxanthineIBA
08/2021
1AcidsIBA
01/2021
1GadoliniumIBA
08/2020
1Phosphorus (Red Phosphorus)IBA
05/2020
1Telmisartan (Micardis)FDA Link
04/2020
1ElectrolytesIBA
04/2020
1MineralocorticoidsIBA
04/2020
1PotassiumIBA
04/2020
1Trimethoprim (Proloprim)FDA LinkGeneric
04/2020
1Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric
04/2020
1Hydrocortisone (Cortisol)FDA LinkGeneric
01/2020
1Adrenocorticotropic Hormone (ACTH)FDA Link
01/2020

Therapy/Procedure

11Therapeutics
04/2024 - 08/2015
6Glycemic Control
12/2023 - 01/2015
1Drug Therapy (Chemotherapy)
01/2021
1Knee Replacement Arthroplasty (Total Knee Replacement)
01/2020